Welcome to the research guide for Literature Searches for Animal Testing Alternatives
The Animal Welfare Act (AWA) regulations require principal investigators to consider alternatives to procedures that may cause more than momentary or slight pain or distress to the animals and provide a written narrative of the methods used and sources consulted to determine the availability of alternatives, including refinements, reductions, and replacements.
"...the performance of a database search remains the most effective and efficient method for demonstrating compliance with the requirement to consider alternatives to painful/distressful procedures." The database search narrative must, at a minimum, include:
Policy #12: Consideration of Alternatives to Painful/Distressful Procedures
From the USDA Animal Care Manual